Tumor-suppressive effects of the ADAMTSs have been linked to the deactivation of key proliferation or survival signaling pathways, including suppression of Erk signaling by ADAMTS8 [136], ADAMTS12 [137] and ADAMTS15 [113], and of Akt/mTOR activity by ADAMTS9 [138]. The gene discussed is ADAMTS15; the disease is neoplasm.