It would be reasonable to suspect that the observed modification of the association between HDLC and eGFR by rs73885319 may be relevant for cardiovascular disease risk, as HDLC has generally been associated with improved cardiovascular health and APOL1 kidney disease risk variants have been associated with increased CVD risk [38] (although the evidence is not consistent across studies [7, 39, 40]). This evidence concerns the gene APOL1 and kidney disorder.