Findings of the present study (e.g., with respect to modifying the generalized effects of PAI-1 and MTHFR gene polymorphisms) may also be important for determining resilience mechanisms against mental health problems like mood disorders and schizophrenia, which severity and treatment outcome were found to be associated with mutations in some coagulation factor genes44, 45, 46, 47. This evidence concerns the gene SERPINE1 and schizophrenia.