The compound PK7088 also raises the melting temperature of the p.Y220C mutant, and triggers cell-cycle arrest and apoptosis in tumor cells in a p.Y220C-dependent manner.77 PK7088 increases the fraction of correctly folded p.Y220C mutant p53 in cells and enhances expression of the TP53 targets p21 and Noxa. This evidence concerns the gene TP53 and neoplasm.