The compound PK7088 also raises the melting temperature of the p.Y220C mutant, and triggers cell-cycle arrest and apoptosis in tumor cells in a p.Y220C-dependent manner.77 PK7088 increases the fraction of correctly folded p.Y220C mutant p53 in cells and enhances expression of the TP53 targets p21 and Noxa. Here, PMAIP1 is linked to neoplasm.