AVP and Hepatic fibrosis: Interestingly, our previous study demonstrated that ADH3 (ADH family class III) is a specific enzyme for retinol metabolism that functions not only in HSCs but also in NK cells and that genetic ablation of ADH3 decreased liver fibrosis by suppressing HSC activation while increasing NK cytotoxicity in carbon tetrachloride (CCl4)- and bile duct ligation (BDL)-induced models of fibrosis [14].