C16orf54 and B-cell chronic lymphocytic leukemia: A proteomics approach is ideally suited to identify membrane proteins that are differentially expressed in primary patient samples compared with samples from nondiseased donors.22, 23, 24 SAIL was first identified as part of a target discovery effort utilizing primary CLL samples, where it was found to be overexpressed in most tumors tested relative to normal PBMCs or BMMCs from nondiseased donors (Figure 1, Supplementary Table S1).