Meta-analysis can combine results from different studies to produce an estimate of the major effect with enhanced precision.The aim of this meta-analysis was to investigate the associations between TLR2 (Arg677Trp, Arg753Gln) and TLR4 (Asp299Gly, Thr399Ile) genetic polymorphisms and susceptibility to IBD. The gene discussed is TLR4; the disease is inflammatory bowel disease.