TLR2 Arg677Trp (R677W, rs12191786) and Arg753Gln (R753Q, rs5743708), and TLR4 Asp299Gly (D299G, rs4986790) and Thr399Ile (T399I, rs4986791) polymorphisms are the most widely discussed SNPs in the investigation of the association between polymorphisms of TLR family and susceptibility to IBD. This evidence concerns the gene TLR2 and inflammatory bowel disease.