Intermittent hypoxia has been shown to induce upregulation of NADPH oxidase catalytic subunit gp91phox and regulatory subunits p22phox and p47phox in the testis; the effect of oxidative stress decreases mRNA and protein expressions of StAR and 3β-HSD and results in hypogonadism [35]. This evidence concerns the gene NCF1 and hypogonadism.