Although the mechanistic link between the AMPK/SIRT1/PGC1α/PhoxO3a/PPARα/UCP2 axis down-regulation and the severe hypertensive disease of SHRSP remains to be explored, it is worthwhile noticing that significant changes in UCP2 gene and protein expression in SHRSP vs SHRSR could be already detected at 8–10 weeks of age, when SBP levels were similar in the two strains. The gene discussed is UCP2; the disease is hypertensive disorder.