EGFR targeted therapy has been disappointing in glioma despite great effort in developing small molecule tyrosine kinase inhibitors (erlotinib, gefitinib, lapatanib, PKI166, neratinib, canertinib, pelitinib), monoclonal antibodies (cetuximab, panitumumab, nimotuzumab), and RNA-based agents (siRNA, antisense oligonucleotides OGX-011) [28]. This evidence concerns the gene EGFR and central nervous system cancer.