PTPN9 and central nervous system cancer: Additional support for the importance of PTPN9 in the pathobiology of BRAFV600E glioma stems from the observation of a two-fold increase in PTPN9 expression in BRAFV600E pediatric astrocytoma (n = 5) relative to BRAF wildtype tumors (n = 29) (p = 0.001), according to the microarray data described in Schiffman et al [7] (Supplementary Figure 4).