Furthermore, the superior protection, as anti-TB vaccine, induced by BCG ΔureC::hly over parental BCG has been described to be associated with inflammasome activation and autophagy [37] and IL-1β has been reported to confer host resistance through the induction of eicosanoids that limits excessive type 1 interferon production and foster mycobacterial containment [38]. This evidence concerns the gene IL1B and tuberculosis.