TWIST1 has been indicated as oncoprotein [14], which, with the support of other transcription factors, like SNAIL1, SLUG and ZEB1, regulates the expression of Cadherins and some other proteins involved in both of EMT and metastasis process, as well as cancer initiation and progression [5, 6, 15, 16, 28–32]. This evidence concerns the gene ZEB1 and cancer.