p21-activated kinase 1 (PAK1), a ubiquitous serine/threonine protein kinase that is widely upregulated in human cancers and plays fundamental role in cellular processes such as invadopodia disassembly [13], cell adhesion and migration [14] and processes that are relevant to metastasis and progression [15,16], epithelial to mesenchymal transition (EMT) [17]. Here, PAK1 is linked to cancer.