In the brain, calcium/ calmodulin-activated AC1 and AC8have drawn much attention through a wide spectrum of functions ranging fromdevelopmental refinement of neural circuits to olfaction, addiction, memoryformation, pain, depression, and neurodegeneration (Hanoune and Defer, 2001; Wang and Storm,2003; Wang and Zhang, 2012; Nicol and Gaspar, 2014). Here, ADCY1 is linked to depressive disorder.