Interestingly, one individual (BRCA2.65) with a history of melanoma had a nonsense variant in CDKN2B (p.Glu35*) that, to our knowledge, is the first reported individual with a germline LoF variant in CDKN2B (also known as p15Ink4b); no germline CDKN2B LoF variants are reported from exome sequencing of 6503 individuals (ESP6500). Here, CDKN2B is linked to melanoma.