WGS was performed on a series of patients from the cancer genetics clinic that included those found to have BRCA1 (n = 88; Supplementary Table 2) or BRCA2 (n = 88; Supplementary Table 3) mutations, as well as those that were not carriers of a BRCA1/2 mutation (n = 82; Supplementary Table 4). This evidence concerns the gene BRCA2 and cancer.