Therefore, further work including tumor markers like alpha fetoprotein (AFP) or β-HCG should be performed and interpreted with reference to the age of neonate as AFP level may be in thousands is normal in neonatal age.[4,5] The surgical approach for a rectal duplication, type-IV SCT, and neuroblastoma is initially similar, i.e., initial mobilization is done through a transverse lower abdomen incision. The gene discussed is AFP; the disease is neuroblastoma.