mTOR activation is frequently observed in cervical squamous cell carcinoma, most HPV(+) head and neck squamous cell carcinomas (HNSCC), HPV(+) oropharyngeal cancers (OPSCC), cervical cancer squamous cell carcinomas (CCSCC) lesions and cell lines [2,17,63,81]. The gene discussed is MTOR; the disease is head and neck squamous cell carcinoma.