So we boldly assume that the KIAA1199/PLXNB3/SEMA5A/CTGF axis may accelerate the proliferation of FLS cells and activate the downstream angiogenic signaling pathways, leading to the formation of the pannus, and erode the cartilage and bone in the progression of RA. The gene discussed is PLXNB3; the disease is rheumatoid arthritis.