Interestingly, the number of samples that were KIAA1199-positive was significantly greater in the active RA than that in the inactive RA group (18 versus 11 in the serum, 21 versus 9 in the synovial fluid, and 20 versus 9 in the synovial tissues).These data suggest that the level of KIAA1199 in serum, synovial fluid and synovial tissues was correlated with the disease activity and was associated with the process of RA (Figure 2). The gene discussed is CEMIP; the disease is rheumatoid arthritis.