GPX3 and diabetes mellitus: A significant inverse association between oxidized-LDL and GPx3 activity after Granulated Brazil nut intake is shown in Fig. 4 with a simple linear regression model (B − 0.434, IC 95 % − 0.829;−0039, β − 0.232, p = 0.032) and it remained significant after adjustment for age, BMI, gender, diabetes and smoking status (B − 0.556, IC 95 % − 0.963;−0148, β − 0.298, p = 0.008).