STUB1 and renal cell carcinoma: To study whether reduced CHIP staining in RCC patients correlates with a worse prognosis, Kaplan-Meier survival curves were plotted using 5-year overall survival (OS) and disease-specific survival (DSS) (n = 304, follow-up time, 60 months) to compare the patients with positive CHIP staining to those with negative staining (Fig. 2).