In multivariate Cox regression analysis, we found that similar to TNM stage, which has been widely accepted as an important prognostic factor for RCC patients, CHIP expression was also an independent prognostic factor for 5-year survival (hazard ratio, 0.739; 95% confidence interval, 0.595–1.074; P = 0.021; Supplementary Table S2). The gene discussed is STUB1; the disease is renal cell carcinoma.