Positive CHIP staining was recorded in 94.1% (32/34) and 51.0% (155/304) of the biopsies in normal renal tissues (NRT) and RCC tissue, respectively (Fig. 1B).We found that CHIP staining was mainly localized in the cytoplasm and the expression of CHIP was significant lower in the carcinoma tissues than the NRT (P = 0.0001). Here, STUB1 is linked to renal cell carcinoma.