Immunohistochemical analysis showed that high c-Myc expression and LDHA expression were 65.56 and 70.00 % in tested specimens, respectively (Fig. 1a–d); elevated c-Myc expression and LDHA expression are closely associated with tumor size (P < 0.001) and TNM stage (P < 0.001) (Table 1). The gene discussed is LDHA; the disease is neoplasm.