In a previous study, more non AIDS-defining events (nADE) were observed among patients with a CD4+ T-cell count <200/μl after 2 years of effective HAART than among those with higher CD4+ counts.[5] However, the association was not confirmed in a model adjusted for age, gender and other confounders, probably because patients were included irrespectively of pre-HAART CD4+ T-cell counts, so that those whose CD4+ counts were >200 cells/μl were more likely to obtain a CD4+ above this threshold. This evidence concerns the gene CD4 and AIDS.