Statistically significant decreased CCL2/CXCL10 and CCL3/CXCL10 among s-CNS compared with HD and CCL19/CXCL10 among s-CNS compared with non-CNS and with HD corroborated decreased circulating monocyte CSF populations vis à vis T lymphocyte trafficking to the CSF (S2 Fig). The gene discussed is CXCL10; the disease is Huntington disease.