EGFR and head and neck squamous cell carcinoma: To verify honokiol-mediated adverse effects on cell viability in HNSCC cells through EGFR/mTOR pathway, FaDu and SCC-1 cells were treated with rapamycin (0, 1, 10, 20, 40 and 100 μM) for 24, 48 and 72 h, and the effect on cell viability was determined using MTT assay.