SOX2 and breast cancer: Similarly, another signature thought to be associated with stemness, the pluripotency factor-associated signature (NANOG-, OCT4-, SOX2-activated transcription factors, NOS-TFs)[46] also failed to predict poor survival in breast cancer, as it was significantly associated with good survival in ‘all’ breast cancer, luminal B and basal breast cancer patients (p = 0.05, p = 0.004 and p = 0.01, respectively).