As shown by our group, the 90-day mortality risk among patients with sepsis is related to the functional programmed cell death 1 genetic polymorphism rs11568821 GG genotype [30], which has been shown to influence transcriptional activity [31] and increase PD-1 expression [32]; PD-1 is thought to play an important role in the so-called sepsis-induced immunosuppression [17]. This evidence concerns the gene PDCD1 and Sepsis.