Additionally, the time to death, (defined as the time of infection to the time cell death manifested by PI staining), in the presence of ∆U or ∆U/T(R149K), was also significantly faster in Crk-/- cells complemented with CrkI-GFP, as compared to the GFP-complemented Crk-/- cells that succumbed to death in response to infection with P. aeruginosa (Fig 5C). The gene discussed is CRK; the disease is infection.