TIMP3 and age-related macular degeneration: These include another complement gene, complement factor I41; genes associated with cholesterol and lipoprotein metabolism, APOE, LIPC, and CETP42; extracellular matrix maintenance gene TIMP3; the atherosclerotic signaling FRK/COL10A1 variant43; the angiogenesis gene VEGFA43; and the TNFRSF10A/LOC389641 region.44 The AMD Gene Consortium recently found seven new disease loci: COL8A1-FILIP1L, IER3-DDR1, SLC16A8, TGFBR1, RAD51B, ADAMTS9, and B3GALTL. 28 A summary of the most significant known genetic contributions to AMD and their proposed roles in its pathogenesis is included in Table 1.