Indeed, since the original study of Y402H by Klein,7 other markers in weak linkage disequilibrium with Y402H have shown stronger associations with AMD, although these generally represent variants comparatively less common within the population.27 However, given that the CCP 7 region binds C-reactive protein and heparan sulfate (as methods of self-recognition),29 and that it is known that the Y402H polymorphism reduces FH binding to both C-reactive protein30 and heparan sulfate in Bruch's membrane,31 it is likely that this variant leads to a dysregulation of complement. This evidence concerns the gene FH and age-related macular degeneration.