An example is the study of the functional consequences of the common Y402H FH polymorphism and the fact that it alters the ability of FH to regulate complement at the site of disease pathogenesis.31,65 Functional studies of this ilk are anticipated to help discover future potential treatments for AMD, and greater knowledge of the “hidden” heritability of AMD will help their success. Here, ILK is linked to age-related macular degeneration.