TCF21 and coronary artery disorder: To better understand the cellular functions of TCF21 in the SMC lineage, and to gain insights into how such functions might contribute to CAD risk, we performed chromatin immunoprecipitation coupled with high throughput sequencing (ChIP-Seq), examined the downstream target loci and genes that harbor TCF21 binding sites, and employed bioinformatic and experimental approaches to investigate how the target genes work together to mediate the risk of CAD.