TCF21 and coronary artery disorder: Employing genes in the GWAS catalog associated with CAD phenotypes, enrichment was found for TCF21 target genes among CAD genes compared to a background of all GWAS genes (CAD, 1.34-fold enrichment, permutation P = 0.014) and these results did not change substantially with exclusion of lipid trait genes (CAD no lipid, 1.34-fold enrichment, permutation P = 0.03) (Table 4).