Consistent with TCF21 CAD target genes being active primarily in the vascular wall, we saw no difference in enrichment between the CAD analyses with and without lipid genes or SNPs being included in the analysis, and no enrichment was found for vascular risk factor traits “LDL cholesterol” and “Total cholesterol.” The enrichment for “Platelets” is not surprising given the known association of platelet number with vascular disease events, and this association could explain some portion of the TCF21 risk for CAD [41–43]. Here, CAD is linked to coronary artery disorder.