Functional SNPs for TCF21 target genes as defined by the RegulomeDB Category I (i.e., SNPs with highest level of evidence that they have functional influence on genes) showed the highest fold enrichment for SNPs with CAD GWAS P-values < 0.01 (Category I fold enrichment 2.06; P = 1.04e-155). The gene discussed is TCF21; the disease is coronary artery disorder.