The traits/phenotypes that we investigated with both analyses included: i) coronary artery disease phenotypes, ii) risk factors that are known to be associated with CAD, iii) non-atherosclerotic vascular diseases that are not specifically associated with CAD, iv) primarily inflammatory disease phenotypes that are known to involve molecular pathways that are also linked to CAD, v) disease phenotypes related to tissues where TCF21 is known to not be expressed and which were predicted negative controls. This evidence concerns the gene TCF21 and coronary artery disorder.