Since the ChIPseq data was generated in HCASMC, a cell type found in the coronary artery, the results of CAD loci enrichment is consistent with the hypothesis that TCF21 regulates a greater than expected number of CAD genes in the vessel wall and that its effect on disease risk may be due in part to its regulation of the network of TCF21 target CAD associated genes. The gene discussed is TCF21; the disease is coronary artery disorder.