The CXCR4-CXCL12 axis, that plays a central role in metastases dissemination, was previously described in ovarian cancer where the involvement of CXCR4-CXCL12 axis in collagen invasion and proliferation was relevant to the metastatic epithelial ovarian cancer39, 40, 41, 42, 43. This evidence concerns the gene CXCR4 and ovarian cancer.