TNFSF11 and major depressive disorder: OP-related fractures impose a heavy burden on individuals and on society, as they often lead to a variety of physical and psychological consequences, including future fractures, depression, functional impairment, pain and disability.[2] In postmenopausal osteoporosis (PMO), receptor activator of nuclear factor-κB ligand (RANKL) is directly associated with osteoclast-mediated bone resorption.[3,4] Osteoprotegerin binds to RANKL and is directly involved in the regulation of the RANK-RANKL pathway.[5]