TNF and colorectal carcinoma: This is in agreement with other previous studies demonstrating the lack of association between polymorphism –308G/A in TNF-α gene and CRC risk.[14–16] The distribution of different TNF-α alleles in our entire CRC population did not differ from the distribution in other European population.[13] According to our knowledge, there was no other report in the literature pointing on this polymorphism in Bulgarian CRC patients.