BMAL1 and cancer: BMAL1 overexpression was shown to inhibit the growth of human colorectal cancer cell lines, increasing their sensitivity to genotoxic agents (oxaliplatin).[70] It has been shown that Tim-depleted cancer cells may become sensitive to doxorubicin (a topoisomerase II inhibitor), making Tim1 a potential anticancer target in therapies based on ATM/ATR damage response pathway inhibition.[72–74]