Several investigations demonstrated that hydantoin derivatives influenced tyrosine kinase activity.[29,30] It has been reported that these compounds could suppress proliferation of lung cancer cells by two pathways, which included inhibiting epidermal growth factor receptor (EGFR) autophosphorylation on the one hand and increasing p53 levels and programmed cell death on the other.[31]. The gene discussed is EGFR; the disease is lung carcinoma.