Of all the amyloidogenic proteins, amyloid beta (Aβ) interactions have been most extensively studied using SPR [31,34–51] followed by prion protein (PrP), which have been implicated in Alzheimer's disease and transmissible spongiform encephalopathy (Prion diseases), respectively.[52–55] Initially, Myszka et al. This evidence concerns the gene PRNP and early-onset autosomal dominant Alzheimer disease.