TP53 and breast carcinoma: Association between carriership of polymorphic variants of genes of DNA repair and the risk for occurrence of TP53 gene mutations may also be observed in breast cancer, where the XPC 939 Gln/Gln, XRCC1 399 Gln/Gln and XPC 499 Ala/Ala homozygous genotypes were associated with increased risk for mutations in TP53(49).