In a large study from 2008, among 25 DNA polymorphisms in genes coding for proteins of DNA repair, maintenance of genome integrity, and progression through cell cycle, several were associated with predictably poorer response in patients with advanced lung cancer treated with platinum derivatives: rs1800975 polymorphism in the 5′-untranslated region of the XPA gene; XPCins83; XPD Lys751Gln; CCNH (cyclin H) Val270Ala (rs2266690); RAD23B Ala249Val (rs1805329); and ERCC1 C8092A polymorphisms (57). Here, CCNH is linked to lung cancer.