Increased mRNA expression of IFN-γ TNF-α, IL-6, IL-8 and IL-12 in tuberculosis granuloma 23 and secretion of cytokines IL-1β, TNF-α and IL-6 in bronchoalveolar lavage fluid from involved sites of pulmonary TB have been reported 24. This evidence concerns the gene IFNG and pulmonary tuberculosis.