TFF3 and hyperinsulinemic hypoglycemia, familial, 4: Furthermore, we propose that uncoupling mitochondria from IFs as a consequence of P1b deficiency, or compromising IF network integrity itself, for example through chemical agents such as polyacrylamide (26), or disruption of IF anchorage at Z-disks (as in the case of P1d deficiency), will lead to mitochondrial dysfunctions.