PKIB(cAMP-dependent protein kinase inhibitor-b) is presumed to be one of the regulatory factors in the PKA pathway that can contribute to cancer cell viability and aggressive phenotype through functional linking between the PKA and Akt pathways [28] PKIB is overexpressed in aggressive castration-resistant PCa and its overexpression correlates with high Gleason score [28]. The gene discussed is AKT1; the disease is cancer.