In addition, FGF23 increased phosphorylation of the NF-κB p65 subunit at its Ser536 site, which we have shown previously is downstream target of ERG [20] Thus FGF23 can alter expression of the TMPRSS2/ERG fusion gene and other genes involved in the neoplastic phenotype in PCa. The gene discussed is NFKB1; the disease is posterior cortical atrophy.