In addition, FGF23 increased phosphorylation of the NF-κB p65 subunit at its Ser536 site, which we have shown previously is downstream target of ERG [20] Thus FGF23 can alter expression of the TMPRSS2/ERG fusion gene and other genes involved in the neoplastic phenotype in PCa. Here, FGF23 is linked to posterior cortical atrophy.