These author spostulated that the reason that a significantly lower adiponectin level was observed in advanced disease-stage patients may be due to the decrease in overall fat mass in advanced lung cancer, leading to the decreased production of adiponectin by subcutaneous adipose tissue [3].Thus, SNP-12140G>A may be merely a susceptibility factor for NSCLC in the Han Chinese population and not associated with lung cancer stage. Here, ADIPOQ is linked to lung cancer.