To confirm these results, in this study, we increased the sample size (from 179 to 319 cases, from 242 to 489 controls) and added two other adiponectin gene promoter SNPs (SNP-11426A>G and SNP-11391G>A) to evaluate the association of these four adiponectin gene promoter SNPs, namely,SNP-12140G>A (rs266730), SNP-11426A>G (rs16861194), SNP-11391G>A (rs17200539) and SNP-11377C>G (rs266729), and their haplotypes with NSCLC risk in a Han Chinese population. The gene discussed is ADIPOQ; the disease is non-small cell lung carcinoma.