Mechanism of acquired resistance to crizotinib was partly mediated by the ROS1 G2032R mutation in a patients with metastatic adenocarcinoma harboring CD74-ROS1 fusion [19] or EGFR pathway activation in a patient with NSCLC harboring SDC4-ROS1 fusion [20]. The gene discussed is ROS1; the disease is non-small cell lung carcinoma.