NOTCH signaling in our LCL model is probably activated by interactions between cells expressing both JAG1 and NOTCH2, which may occur in the tight clumps typically formed in B cells after EBV infection.31, 32 Upregulation of JAG1 and HES1 expression was also detected in cells expressing high levels of endogenous TERT transcripts (data not shown). The gene discussed is NOTCH2; the disease is Epstein-Barr virus infection.