In the present study, we corroborated that survivin overexpression in human HNSCC cell lines and tissues, which was correlated with cell cycle regulators, autophagic genes, and mTOR pathway, as indicated by the compelling correlations of p-S6, p-Rb, Cyclin D1, LC3 and LAMP2 in human HNSCC. The gene discussed is LAMP2; the disease is head and neck squamous cell carcinoma.