In the present study, we corroborated that survivin overexpression in human HNSCC cell lines and tissues, which was correlated with cell cycle regulators, autophagic genes, and mTOR pathway, as indicated by the compelling correlations of p-S6, p-Rb, Cyclin D1, LC3 and LAMP2 in human HNSCC. This evidence concerns the gene CCND1 and head and neck squamous cell carcinoma.