The anti-inflammatory cytokine IL1RN was also differentially expressed in response to infection, following the same expression pattern as IL1B and IL8. As seen in Table 2, the expression of cytokines involved in Th17 differentiation (IL6, IL1B, IL17), was highly correlated with expression of bacterial genes involved in synthesis of the outer membrane (OM) as well as apxIIA and comEA. Correlation was for the most part significant and positive except for correlation with ompA and tolA, which was negative. The gene discussed is IL6; the disease is infection.