ANGPT2 and Plasmodium falciparum malaria: Although Ang-2 has a variety of context-dependent effects on endothelial cells, by enhancing endothelial activation and increasing vascular permeability it is thought to play an important role in the pathogenesis of acute lung injury and multi-organ failure [36, 39], both of which are complications of falciparum malaria with a high attributable mortality [20].