ANGPT2 and acute kidney injury: Admission plasma Ang-2 concentrations were significantly greater in patients who died (median (IQR) 21.9 (13.4–29.4) ng/mL) than in survivors (median (IQR) 14.9 (9.8–29.3) ng/mL) (P = 0.035) and were correlated with the presence of an elevated plasma lactate (P = 0.001) (Fig. 3), multi-organ dysfunction (P = 0.004) (Fig. 4), AKI (P = 0.0001) (Fig. 5) and estimated parasite biomass (rs = 0.35, P <0.001).