Synergistic interactions between trametinib and ICG-001 were investigated in a panel of cell lines, including three CTNNB1-wild type colon cancer cell lines, three CTNNB1-mutant colon cancer cell lines, and a pair of CTNNB1-mutant and CTNNB1-wild type lung cancer cell lines (Fig 8 and S3 Fig). This evidence concerns the gene CTNNB1 and malignant colon neoplasm.