Further work in APAP overdose patients demonstrated that plasma miR122 levels at presentation to hospital correlated with peak ALT and peak international normalised ratio (INR) during the period of hospitalisation and that in patients with normal ALT at presentation, miR122 levels were predictive of development of ALI and more sensitive than ALT for identifying ALI in patients presenting within eight hours of APAP overdose [19]. The gene discussed is GPT; the disease is acute respiratory distress syndrome.