The primary findings of the present investigation include (1) CSMG neurons isolated from septic rats exhibit a larger membrane surface area than controls; (2) sepsis induced a rightward shift of the NE concentration response curve, indicative of decreased NE potency in N-type Ca2+ channel modulation; (3) a subpopulation of CSMG neurons expresses MOR; and (4) both opioid pharmacological profiles and the propionate-mediated inhibition of Ca2+ currents are not altered by sepsis. This evidence concerns the gene OPRM1 and Sepsis.