For example, compared with glucose deprivation (GD)-induced autophagy, ANE 30–100K-induced AMPK activation is necessary for ERK activation in Jurkat T cells (Fig 7), whereas AMPK activation was shown to inhibit ERK in GD-induced autophagy in colon carcinoma HCT116 cells [43]. Here, PRKAA1 is linked to colon carcinoma.