CASP7 and ovarian adenocarcinoma: On the other hand CS knockdown in human ovarian adenocarcinoma cell line SKOV3 and A2780 cells resulted in dysregulation of cell metabolism and downregulation of proliferation by decreasing phosphorylation of the extracellular signal-regulated kinase (ERK), a key component in the control of cell growth, and increasing of CASP7 encoded Caspase 7 involved in the caspase activation cascade responsible for the execution of apoptosis [11].